![]() ![]() (Remember, as we discussed in Study Unit 2, not all locks are opened by a key. For this reason, a modification called the induced-fit theory has been proposed.Ī key-operated lock mechanism is simply any type of lock that’s opened and closed by inserting and turning a key. Not all experimental evidence can be adequately explained by using the so-called rigid enzyme model assumed by the lock and key theory. Is the lock and key theory adequately explained? Lock and key mechanism is a mechanism introduced in 1890 by Emil Fischer to explain binding between the active site of an enzyme and a substrate molecule. What is the lock and key mechanism in enzymes?Ī model used to explain why enzymes are so specific in their activity is called lock-and-key mechanism. The active site was considered to have a fixed structure (the lock), which exactly matched the structure of a specific substrate (the key). When was the lock and key mechanism introduced? As, these active sites (can be called locks) are very specific and only few molecules (can be called keys) can bind them, this model of enzyme working is called Lock and Key mechanism. Why is it called a lock and key mechanism?Įxplanation: Enzymes are proteins which catalyse a single or various biological processes in a cell. It supposes that the substrate fits perfectly into the active site of the enzyme. The lock and key model assumes that the active site of the enzyme and the substrate are equal shaped. The lock and key model also called Fisher’s theory is one of two models which describe the enzyme-substrate interaction. 4 Is the lock and key theory adequately explained?ġ Definition.3 What is the lock and key mechanism in enzymes?.2 Why is it called a lock and key mechanism?. ![]()
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